Schizophrenia

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  • Treatments of Negative Symptoms in Schizophrenia: Meta-Analysis of 168 Randomized Placebo-Controlled Trials

    Schizophrenia Bulletin - Advance Access
    Fusar-Poli, P., Papanastasiou, E., Stahl, D., Rocchetti, M., Carpenter, W., Shergill, S., McGuire, P.
    20 Dec 2014 | 1:42 am
    Objectives:Existing treatments for schizophrenia can improve positive symptoms, but it is unclear if they have any impact on negative symptoms. This meta-analysis was conducted to assess the efficacy of available treatments for negative symptoms in schizophrenia. Methods:All randomized-controlled trials of interventions for negative symptoms in schizophrenia until December 2013 were retrieved; 168 unique and independent placebo-controlled trials were used. Negative symptom scores at baseline and follow-up, duration of illness, doses of medication, type of interventions, and sample…
  • Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning

    Schizophrenia Research
    Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Jie Zhang, Qing Chang, Yufen Ou, Bin Sun, Yuping Ning, Hongbo He
    18 Dec 2014 | 4:00 pm
    Lack of insight into illness has long been recognized as a central characteristic of schizophrenia. Although recent theories have emphasized neurocognitive dysfunction as a central impairment in schizophrenia it remains unclear whether the lack of insight in schizophrenia is more strongly associated with measures of symptom severity or neuropsychological dysfunction.
  • Discovery of novel drug target may lead to better treatment for schizophrenia

    Schizophrenia News
    12 Dec 2014 | 7:46 am
    Scientists at the Centre for Addiction and Mental Health have identified a novel drug target that could lead to the development of better antipsychotic medications. Dr. Fang Liu, Senior Scientist in CAMH's Campbell Family Mental Health Research Institute and Professor in the Department of Psychiatry, University of Toronto, and her team published their results online in the journal Neuron.
  • Phosphodiesterase 10A inhibitor MP-10 effects in primates: comparison ...

    Schizophrenia News
    12 Dec 2014 | 12:01 pm
    Phosphodiesterase 10A is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Similar to dopamine Da receptor antagonists acting on indirect pathway neurons, PDE10A inhibitors have shown behavioral effects in rodent models that predict antipsychotic efficacy.
  • Impact of DSM-5 Changes on the Diagnosis and Acute Treatment of Schizophrenia

    Schizophrenia Bulletin - Advance Access
    Mattila, T., Koeter, M., Wohlfarth, T., Storosum, J., van den Brink, W., de Haan, L., Derks, E., Leufkens, H., Denys, D.
    20 Dec 2014 | 1:42 am
    Objective:To examine the consequences and validity of changes in Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnostic criteria for schizophrenia, eg, omission of subtypes, using a large dataset of double-blind, randomized, placebo-controlled schizophrenia trials.Methods:Data from 22 short-term efficacy registration trials of second generation antipsychotics for the treatment of acute psychotic episodes in patients with schizophrenia (N = 5233), submitted to the Dutch regulatory authority were analyzed. We examined whether patients in these pre-DSM-5 trials met the…
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    schizophrenia - Google News

  • The New Genetics of Schizophrenia - Yahoo Health

    20 Dec 2014 | 7:01 am
    Yahoo HealthThe New Genetics of SchizophreniaYahoo HealthThe largest study ever conducted of people with schizophrenia has found 83 new gene locations, some in surprising places — findings that will allow researchers to pursue new theories about what causes the disease and how to treat it. The work of
  • Flashback Friday: Did Gollum have schizophrenia or multiple personality disorder? - Discover Magazine (blog)

    19 Dec 2014 | 6:19 am
    Discover Magazine (blog)Flashback Friday: Did Gollum have schizophrenia or multiple personality disorder?Discover Magazine (blog)Schizophrenia was the most common diagnosis (25 students), followed by multiple personality disorder (three). On initial consideration schizophrenia seems a reasonable diagnosis. However, in the context of the culture at the time it is unlikely
  • IMPD looking for missing schizophrenia patient - Fox 59

    18 Dec 2014 | 9:58 am
    Fox 59IMPD looking for missing schizophrenia patientFox 59INDIANAPOLIS (Dec. 18, 2014) – Indianapolis Metropolitan police are looking for a man who walked away from a northwest side group home and hasn't been seen since. James Christensen, 59, has been diagnosed with schizophrenia. Police say he left the ...Police searching for missing man with schizophreniaWRTV Indianapolisall 3 news articles »
  • Alkermes Starts Phase I Study on Schizophrenia Candidate - Analyst Blog - Nasdaq

    16 Dec 2014 | 3:59 pm
    Alkermes Starts Phase I Study on Schizophrenia Candidate - Analyst BlogNasdaqhas started a phase I study of extended dosing intervals on aripiprazole lauroxil. Aripiprazole lauroxil, a long-acting injectable atypical antipsychotic, is currently under FDA review for the treatment of schizophrenia.and more »
  • Psychiatrist testified Lasley had no signs of schizophrenia or psychosis in 2004 - KCRG

    12 Dec 2014 | 11:22 am
    KCRGPsychiatrist testified Lasley had no signs of schizophrenia or psychosis in 2004KCRGGordon Lasley Jr. had substance abuse issues, anti-social traits, anger management issues, and spent more than a year in treatment programs, according to Friday's testimony by psychiatrist and officials with juvenile treatment centers and programs and more »
 
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    Schizophrenia News

  • Report released into Ontario man's death at mental health facility

    19 Dec 2014 | 2:34 pm
    The family of an Ontario man who died while in custody at a mental health facility in Penetenguishine says a coroner inquest has given them a sense of closure. "I wait five years," said Aganeh's mother Ikram Said.
  • Less than half of UK prescriptions for antipsychotics issued for main licensed conditions

    18 Dec 2014 | 4:38 pm
    Less than half of UK prescriptions for antipsychotic drugs are being issued to treat the serious mental illnesses for which they are mainly licensed, reveals research published in the online journal BMJ Open . Instead, they may often be prescribed 'off label' to older people with other conditions, such as anxiety and dementia, despite the greater risk of potentially serious side effects in this age group, the findings indicate.
  • Phosphodiesterase 10A inhibitor MP-10 effects in primates: comparison ...

    12 Dec 2014 | 12:01 pm
    Phosphodiesterase 10A is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Similar to dopamine Da receptor antagonists acting on indirect pathway neurons, PDE10A inhibitors have shown behavioral effects in rodent models that predict antipsychotic efficacy.
  • Discovery of novel drug target may lead to better treatment for schizophrenia

    12 Dec 2014 | 7:46 am
    Scientists at the Centre for Addiction and Mental Health have identified a novel drug target that could lead to the development of better antipsychotic medications. Dr. Fang Liu, Senior Scientist in CAMH's Campbell Family Mental Health Research Institute and Professor in the Department of Psychiatry, University of Toronto, and her team published their results online in the journal Neuron.
  • FDA warns Pfizer's antipsychotic could cause fatal skin reaction

    11 Dec 2014 | 7:51 am
    Pfizer Inc's antipsychotic Geodon and generic versions of the drug can trigger a potentially fatal skin reaction, the U.S. Food and Drug Administration warned on Thursday. A new warning has been added to the drug's label to describe the condition - known as Drug Reaction with Eosinophilia and Systemic Symptoms - which may start as a rash and spread all over.
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    MedWorm: Schizophrenia

  • Multiparametric mapping of neurological soft signs in healthy adults

    20 Dec 2014 | 3:00 pm
    This study evaluated the relationship between NSS levels and abnormalities of subcortical and cortical structures in healthy individuals. High-resolution MRI data at 3 Tesla were obtained from 68 healthy individuals. Automated segmentation of caudate nucleus, putamen, globus pallidus, thalamus, and brainstem was performed using both FSL-FIRST and Freesurfer. The surface-based analysis via Freesurfer enabled calculation of cortical thickness, area and folding (local gyrification index). NSS were examined on the Heidelberg Scale and related to both subcortical and cortical measurements. Using…
  • Prayers, Facebook and Weight Loss

    19 Dec 2014 | 6:30 pm
    "When people talk to God, it is called prayer. When God talks to people, they call it schizophrenia." -- Dr. Jim Roach in his upcoming book, God's House Calls "Just like a prayer. Your voice can take me there" -- Madonna Until recently, my attitude toward prayer had been guided by President Harry S. Truman who said that "people who pray the loudest are the ones you lock your hen house from." I've always been intensely suspicious of anyone who seems too overt in their embrace of prayer, especially if the conversation deviates to matters concerning my checkbook or wallet. Praying out loud was…
  • Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation

    19 Dec 2014 | 3:00 pm
    Publication date: February 2015 Source:Brain, Behavior, and Immunity, Volume 44 Author(s): Mauricio Rosas-Ballina , Sergio I. Valdés-Ferrer , Meghan E. Dancho , Mahendar Ochani , David Katz , Kai Fan Cheng , Peder S. Olofsson , Sangeeta S. Chavan , Yousef Al-Abed , Kevin J. Tracey , Valentin A. Pavlov Inflammatory conditions characterized by excessive immune cell activation and cytokine release, are associated with bidirectional immune system-brain communication, underlying sickness behavior and other physiological responses. The vagus nerve has an important role in this communication by…
  • IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia

    19 Dec 2014 | 3:00 pm
    Publication date: February 2015 Source:Brain, Behavior, and Immunity, Volume 44 Author(s): Emily G. Severance , Kristin L. Gressitt , Armin Alaedini , Cathrin Rohleder , Frank Enning , J. Malte Bumb , Juliane K. Müller , Emanuel Schwarz , Robert H. Yolken , F. Markus Leweke Schizophrenia is a complex brain disorder that may be accompanied by idiopathic inflammation. Classic central nervous system (CNS) inflammatory disorders such as viral encephalitis or multiple sclerosis can be characterized by incongruent serum and cerebrospinal fluid (CSF) IgG due in part to localized intrathecal…
  • Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms

    19 Dec 2014 | 3:00 pm
    Orexin A and B, two hypothalamic neuropeptides also known as hypocretin 1 and 2, are endogenous ligands of a pair of Gq-protein coupled receptors, OX1 and OX2 (de Lecea et al., 1998; Sakurai et al., 1998). Orexin-containing neurons are located only in the lateral hypothalamus and perifornical area. However, their projection fibers are widely distributed in the central nervous system, including the basal forebrain, thalamus, and prefrontal cortex (PFC), crucial areas involved in attention and cognitive functions (Peyron et al., 1998). (Source: Psychoneuroendocrinology)
 
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    About.com Schizophrenia: What's Hot Now

  • Schizophrenia Symptoms and Diagnosis

    schizophrenia.guide@about.com
    21 Dec 2014 | 4:35 am
    What are the main symptoms of schizophrenia? How is a diagnosis of schizophrenia made?
  • How Schizophrenia Is Diagnosed

    schizophrenia.guide@about.com
    21 Dec 2014 | 4:35 am
    The better you understand the language and the process of diagnosing schizophrenia, the better you can communicate with your doctor. Remember that only a psychologist or psychiatrist can rule out or diagnose schizophrenia.
  • What It's Like to Have Schizophrenia

    schizophrenia.guide@about.com
    21 Dec 2014 | 4:35 am
    In schizophrenia, the most basic processes of perceiving and thinking are affected by the illness. Whether you want your loved ones to understand you better, are concerned for someone who's ill, or are simply curious, this article describes the internal experience of delusions, hallucinations, and more. Page 2.
  • The Positive and Negative Symptoms of...

    schizophrenia.guide@about.com
    21 Dec 2014 | 4:35 am
    Are you having experiences that seem unreal? Are you concerned about strange behavior in a loved one? Learn to understand and describe the symptoms of schizophrenia, so that you can communicate them to a doctor.
  • What Causes Schizophrenia?

    schizophrenia.guide@about.com
    21 Dec 2014 | 4:35 am
    Schizophrenia is a complex disease of the brain. Although scientists continue to learn about schizophrenia, the exact cause of the illness is still not known. This article from your About Guide to Schizophrenia explains the current understanding about the causes of schizophrenia.
 
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    About.com Schizophrenia: Most Popular Articles

  • Schizophrenia Early Signs

    21 Dec 2014 | 6:28 am
    It is important to recognize schizophrenia as early as possible. Early diagnosis is the foundation for early intervention, which is the path to recovery,
  • Negative Symptoms

    21 Dec 2014 | 6:28 am
    Definitions of the term, negative symptoms.
  • What It's Like to Have Schizophrenia

    21 Dec 2014 | 6:28 am
    In schizophrenia, the most basic processes of perceiving and thinking are affected by the illness. Whether you want your loved ones to understand you better, are concerned for someone who's ill, or are simply curious, this article describes the internal experience of delusions, hallucinations, and more.
  • Aripiprazole/Abilify Drug Profile

    21 Dec 2014 | 6:28 am
    Aripiprazole/Abilify Drug Profile
  • Atypical Antipsychotic Drugs Used to Treat...

    21 Dec 2014 | 6:28 am
    In the early 1990s a new class of drugs were developed to treat the psychotic symptoms of schizophrenia. These drugs, the atypical antipsychotics, have proven generally as effective as the antispychotics developed decades earlier, with fewer extrapyrimidal side effects. This list of the atypical antipsychotics provides links to drug safety information from the drug manufacturers' websites.
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    Schizophrenia Bulletin - Advance Access

  • The Stress of the Street for Patients With Persecutory Delusions: A Test of the Symptomatic and Psychological Effects of Going Outside Into a Busy Urban Area

    Freeman, D., Emsley, R., Dunn, G., Fowler, D., Bebbington, P., Kuipers, E., Jolley, S., Waller, H., Hardy, A., Garety, P.
    20 Dec 2014 | 1:42 am
    Background:For many patients with persecutory delusions, leaving home and going into crowded streets is a key clinical problem. In this study we aimed to inform treatment development by determining the psychological mechanisms whereby busy urban environments increase paranoia. In a randomized design with prespecified mediation analysis, we compared the effects on patients of going outside into a busy social environment with staying inside. Methods:Fifty-nine patients with current persecutory delusions, in the context of nonaffective psychosis, reporting fears when going outside were assessed…
  • Impact of DSM-5 Changes on the Diagnosis and Acute Treatment of Schizophrenia

    Mattila, T., Koeter, M., Wohlfarth, T., Storosum, J., van den Brink, W., de Haan, L., Derks, E., Leufkens, H., Denys, D.
    20 Dec 2014 | 1:42 am
    Objective:To examine the consequences and validity of changes in Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnostic criteria for schizophrenia, eg, omission of subtypes, using a large dataset of double-blind, randomized, placebo-controlled schizophrenia trials.Methods:Data from 22 short-term efficacy registration trials of second generation antipsychotics for the treatment of acute psychotic episodes in patients with schizophrenia (N = 5233), submitted to the Dutch regulatory authority were analyzed. We examined whether patients in these pre-DSM-5 trials met the…
  • Treatments of Negative Symptoms in Schizophrenia: Meta-Analysis of 168 Randomized Placebo-Controlled Trials

    Fusar-Poli, P., Papanastasiou, E., Stahl, D., Rocchetti, M., Carpenter, W., Shergill, S., McGuire, P.
    20 Dec 2014 | 1:42 am
    Objectives:Existing treatments for schizophrenia can improve positive symptoms, but it is unclear if they have any impact on negative symptoms. This meta-analysis was conducted to assess the efficacy of available treatments for negative symptoms in schizophrenia. Methods:All randomized-controlled trials of interventions for negative symptoms in schizophrenia until December 2013 were retrieved; 168 unique and independent placebo-controlled trials were used. Negative symptom scores at baseline and follow-up, duration of illness, doses of medication, type of interventions, and sample…
  • Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study

    Cederlof, M., Lichtenstein, P., Larsson, H., Boman, M., Ruck, C., Landen, M., Mataix-Cols, D.
    15 Dec 2014 | 12:02 am
    Obsessive-compulsive disorder (OCD) often co-occurs with psychotic and bipolar disorders; this comorbidity complicates the clinical management of these conditions. In this population-based longitudinal and multigenerational family study, we examined the patterns of comorbidity, longitudinal risks, and shared familial risks between these disorders. Participants were individuals with a diagnosis of OCD (n = 19814), schizophrenia (n = 58336), bipolar disorder (n = 48180), and schizoaffective disorder (n = 14904) included in the Swedish Patient Register between January 1969 and December 2009;…
  • The Key Role of Emotions in the Schizophrenia Puzzle

    Ciompi, L.
    6 Dec 2014 | 5:01 am
    The aim of this paper is to show that the dynamic effects of emotions in schizophrenia are underestimated and partly misunderstood. This may be related to an insufficient consideration for certain key properties of emotions, especially their energizing effects. After introductory remarks on current notions on emotions in schizophrenia, I present an alternative view based on my concept of affect-logic and discuss some of its therapeutic implications.
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    Schizophrenia Research

  • What is more familiar than I? Self, other and familiarity in schizophrenia

    Aurely Ameller, Antoine Dereux, Caroline Dubertret, Guillaume Vaiva, Pierre Thomas, Delphine Pins
    18 Dec 2014 | 4:00 pm
    Familiarity disorders (FDs) critically impact social cognition in persons with schizophrenia. FDs can affect both relationships with people familiar to the patient and the patient's relationship with himself, in the case of a self-disorder. Skin conductance response (SCR) studies have shown that familiar and unknown faces elicit the same emotional response in persons with schizophrenia with FD. Moreover, in control subjects, one's own face and familiar faces have been shown to activate strongly overlapping neural networks, suggesting common processing.
  • Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning

    Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Jie Zhang, Qing Chang, Yufen Ou, Bin Sun, Yuping Ning, Hongbo He
    18 Dec 2014 | 4:00 pm
    Lack of insight into illness has long been recognized as a central characteristic of schizophrenia. Although recent theories have emphasized neurocognitive dysfunction as a central impairment in schizophrenia it remains unclear whether the lack of insight in schizophrenia is more strongly associated with measures of symptom severity or neuropsychological dysfunction.
  • Persistence of effectiveness of cognitive remediation interventions in schizophrenia: A 1-year follow-up study

    Giacomo Deste, Stefano Barlati, Paolo Cacciani, Luca DePeri, Roberto Poli, Emilio Sacchetti, Antonio Vita
    18 Dec 2014 | 4:00 pm
    Cognitive remediation interventions are effective in patients with schizophrenia, but the durability of their effects is still under debate. This study aimed to investigate the 1-year persistence of the effectiveness of cognitive remediation.
  • Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia

    Kelly A. Allott, Simon Rice, Cali F. Bartholomeusz, Claudia Klier, Monika Schlögelhofer, Miriam R. Schäfer, G. Paul Amminger
    18 Dec 2014 | 4:00 pm
    Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and also in those at ultra-high risk for the illness. Whether these impairments are an endophenotype for schizophrenia is unclear. To examine the heritability of emotion recognition, the aim of this study was to examine whether facial and prosody emotion recognition deficits, particularly for negative emotions, are also present in unaffected first-degree relatives of people with schizophrenia.
  • Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia

    C. Bois, L. Levita, I. Ripp, D.C.G. Owens, E.C. Johnstone, H.C. Whalley, S.M. Lawrie
    17 Dec 2014 | 4:00 pm
    Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterations may be evident at any given time-point, or whether they progress over time. To investigate this, structural brain scans were acquired at two time-points (mean scan-interval 1.87years) in a cohort of young unaffected individuals at high familial risk of schizophrenia…
 
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    Schizophrenia Research

  • Persistence of effectiveness of cognitive remediation interventions in schizophrenia: A 1-year follow-up study

    Giacomo Deste, Stefano Barlati, Paolo Cacciani, Luca DePeri, Roberto Poli, Emilio Sacchetti, Antonio Vita
    18 Dec 2014 | 4:00 pm
    Cognitive remediation interventions are effective in patients with schizophrenia, but the durability of their effects is still under debate. This study aimed to investigate the 1-year persistence of the effectiveness of cognitive remediation.
  • Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning

    Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Jie Zhang, Qing Chang, Yufen Ou, Bin Sun, Yuping Ning, Hongbo He
    18 Dec 2014 | 4:00 pm
    Lack of insight into illness has long been recognized as a central characteristic of schizophrenia. Although recent theories have emphasized neurocognitive dysfunction as a central impairment in schizophrenia it remains unclear whether the lack of insight in schizophrenia is more strongly associated with measures of symptom severity or neuropsychological dysfunction.
  • Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia

    Kelly A. Allott, Simon Rice, Cali F. Bartholomeusz, Claudia Klier, Monika Schlögelhofer, Miriam R. Schäfer, G. Paul Amminger
    18 Dec 2014 | 4:00 pm
    Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and also in those at ultra-high risk for the illness. Whether these impairments are an endophenotype for schizophrenia is unclear. To examine the heritability of emotion recognition, the aim of this study was to examine whether facial and prosody emotion recognition deficits, particularly for negative emotions, are also present in unaffected first-degree relatives of people with schizophrenia.
  • What is more familiar than I? Self, other and familiarity in schizophrenia

    Aurely Ameller, Antoine Dereux, Caroline Dubertret, Guillaume Vaiva, Pierre Thomas, Delphine Pins
    18 Dec 2014 | 4:00 pm
    Familiarity disorders (FDs) critically impact social cognition in persons with schizophrenia. FDs can affect both relationships with people familiar to the patient and the patient's relationship with himself, in the case of a self-disorder. Skin conductance response (SCR) studies have shown that familiar and unknown faces elicit the same emotional response in persons with schizophrenia with FD. Moreover, in control subjects, one's own face and familiar faces have been shown to activate strongly overlapping neural networks, suggesting common processing.
  • Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia

    C. Bois, L. Levita, I. Ripp, D.C.G. Owens, E.C. Johnstone, H.C. Whalley, S.M. Lawrie
    17 Dec 2014 | 4:00 pm
    Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterations may be evident at any given time-point, or whether they progress over time. To investigate this, structural brain scans were acquired at two time-points (mean scan-interval 1.87years) in a cohort of young unaffected individuals at high familial risk of schizophrenia…
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    Schizophrenia News -- ScienceDaily

  • Less than half of UK prescriptions for antipsychotics issued for main licensed conditions

    18 Dec 2014 | 6:00 pm
    Less than half of UK prescriptions for antipsychotic drugs are being issued to treat the serious mental illnesses for which they are mainly licensed, reveals research. Instead, they may often be prescribed 'off label' to older people with other conditions, such as anxiety and dementia, despite the greater risk of potentially serious side effects in this age group, the findings indicate.
  • Neuronal circuits filter out distractions in brain

    15 Dec 2014 | 8:42 am
    Scientists have hypothesized for decades about how the brain filters out distractions, but it has been challenging to find evidence to support the theories. Now, researchers have identified a neural circuit in the mouse brain that controls attention and sensory processing, providing insight into how the brain filters out distractions. The work has implications for devastating psychiatric disorders such as schizophrenia that are characterized at least in part by significant attention deficits.
  • Discovery of novel drug target may lead to better treatment for schizophrenia

    9 Dec 2014 | 7:18 am
    A novel drug target that could lead to the development of better antipsychotic medications has been discovered by researchers. Current treatment for patients with schizophrenia involves taking medications that block or interfere with the action of the neurotransmitter dopamine. However, because this D2-blocking action may cause unwanted side-effects, such as slow gait, stiffness and tremor, the team looked for new ways to interfere with the action of D2 receptors, without causing these side-effects.
  • Medications for patients with first episode psychosis may not meet guidelines

    4 Dec 2014 | 4:43 am
    Many patients with first-episode psychosis receive medications that do not comply with recommended guidelines for first-episode treatment, researchers have found. Current guidelines emphasize low doses of antipsychotic drugs and strategies for minimizing the side effects that might contribute to patients stopping their medication. A NIH-funded study finds that almost 40 percent of people with first-episode psychosis in community mental health clinics across the country might benefit from medication treatment changes.
  • Schizophrenia may be triggered by excess protein during brain development

    24 Nov 2014 | 5:10 am
    A gene associated with schizophrenia plays a role in brain development and may help to explain the biological process of the disease, according to new research. Researchers saytoo much protein expressed by the NOS1AP gene, which has been associated with schizophrenia, causes abnormalities in brain structure and faulty connections between nerve cells that prevent them from communicating properly.
 
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    Schizophrenia Society of Nova Scotia

  • The "From Recovery to Discovery" Mental Health Peer Support Group - Halifax

    19 Dec 2014 | 4:00 am
    Thursday, January 8th, 6:30 pmMeetingsEvery Thursday Evening6:30 pm to 8:30 pmCommunity RoomAtlantic Superstore – Barrington Street 1075 Barrington StreetHalifax, Nova Scotia Plenty of free parking!The Atlantic Superstore – Barrington Street is on the 3, 7, 9, and 41 Metro Transit bus routes.The From Recovery to Discovery Mental Health Peer Support Group is open to anyone affected by any type of mental illness, and this includes family members and friends.Free! Thursday, January 8th, 2015, 6:30 pm A Mental Health Peer Support Group Meeting Topic: To Be AnnouncedAbout the From…
  • Families Matter in Mental Health: An Education and Support Program -- Halifax

    19 Dec 2014 | 3:30 am
    Begins Tuesday, January 13th, 2015, at 6:30 pmBayers Road Community Mental HealthBayers Road Centre7071 Bayers Road, Suite 109Halifax, Nova ScotiaFor further information and to register, please call the Healthy Minds Cooperative at 902-404-3504, or send an email to hmnavigator@eastlink.ca.Please click on the image to magnify it.To download a PDF version of the above poster, please click here.
  • Information / Feedback Session - Together We Can

    19 Dec 2014 | 3:00 am
    Tuesday, January 20th, 20156:00 pm to 7:30 pmPlease click on the image to magnify it.To download a PDF version of the above flyer, please click here.For background information of the "Together We Can" strategy, visit: http://novascotia.ca/dhw/mental-health/mental-health-addiction-strategy.asp
  • Getting Mental Health Crisis Support in Nova Scotia

    17 Dec 2014 | 4:00 am
    Call (902) 429-8167 or 1-888-429-8167 (toll free)The Mental Health Mobile Crisis Team (MHMCT) provides intervention and short term crisis management for children, youth and adults experiencing a mental health crisis. They offer 24/7 telephone intervention throughout Nova Scotia - (902) 429-8167 or 1-888-429-8167 (toll free) - and mobile response (1:00 pm to 1:00 am) in areas served by Halifax Regional Police including Halifax, Dartmouth and Bedford.Note that this video is two years old and it does not mention the 24/7 telephone crisis intervention service that is now available throughout Nova…
  • How to refer someone to the Nova Scotia Early Psychosis Program

    17 Dec 2014 | 3:30 am
    From the Nova Scotia Early Psychosis Program (NSEPP) website:Because NSEPP is located in Halifax, within the largest of the Nova Scotia health regions; Capital Health, the program provides direct clinical services to residents of the Capital Health district.Referrals to NSEPP can be made by anyone, including mental health care professionals, family physicians, community agencies, educators and school counselors, family members, friends and any young person who suspects they may be suffering from a first episode of psychosis.Criteria for referral of individuals who reside in the Capital Health…
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    schizophrenic.com

  • Perceived social status and power may be at the root of mental illness

    M Tyler
    16 Dec 2014 | 7:18 am
    Mental health may have less to do with worldly status and more to do with feelings of self-worth, a new study from the University of California, Berkeley reports. Decreased feelings of self-worth were linked to mental health conditions like bipolar disorder, anxiety, depression and narcissistic personality disorder, the researchers found. In the study of more than 600 young men and women, perceived social status seemed to be at the heart of mental illness. "People prone to depression or anxiety reported feeling little sense of pride in their accomplishments and little sense of power," said…
  • Drug guidelines for first-episode psychosis may be failing patients

    M Tyler
    10 Dec 2014 | 10:06 am
    Current guidelines about medication may need revision when it comes to patients being treated for first-episode psychosis, according to new research published in the American Journal of Psychiatry. Almost 40 percent of people with first-episode psychosis could benefit from medication treatment changes, the study reports, which could help minimize the side effects that often cause patients to stop taking their medication. To accomplish beneficial changes, the authors recommend additional education for physicians or mental health practitioners who prescribe medication to these vulnerable…
  • Pediatricians can help detect mental illness in new moms

    M Tyler
    3 Dec 2014 | 10:32 am
    After a woman gives birth, her own doctor visits may become less frequent as she focuses more on the health of her growing baby. But this trend can leave many women vulnerable to mental health issues that go undetected, a new study reports, and can set them up for problems later in life. A report released by the Child Health and Development Institute (CHDI) suggests that pediatricians could act as a roadblock to this progression, playing a vital role in spotting mental illness in new moms. "The implications of not addressing maternal mental health are lifelong," Lisa Honigfeld, CHDI vice…
  • Excess protein in brain could trigger schizophrenia

    M Tyler
    24 Nov 2014 | 8:40 am
    The area of the brain responsible for conscious thought, spatial reasoning and language development could be compromised by the overabundance of a particular protein in people with schizophrenia, new research suggests. A study from Rutgers University found that too much protein expressed by the NOS1AP gene can cause abnormalities in the structure and function of the neocortex, resulting in poor connections between nerve cells. Bonnie Firestein, professor in the Department of Cell Biology and Neuroscience at Rutgers, and her colleagues tested rats who had varying levels of NOS1AP. "When the…
  • Fish oil supplements may help prevent psychosis

    M Tyler
    20 Nov 2014 | 8:20 am
    A small study presented at the Early Psychosis Conference in Tokyo suggests that fish oil may give protective benefits against psychosis in young people at risk for the condition. Fish oil is rich in omega-3 fatty acids, which have been linked to better brain health and potentially the ability to ward off dementia. Patients in the study received four capsules of fish oil per day with two types of omega-3 fatty acids: 700 milligrams of EPA and 480 milligrams of DHA. The participants also took 7.6 milligrams of vitamin E. Another control group of patients received placebo pills, and both groups…
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    Schiz Life

  • Schizophrenia and Seasonal Affective Disorder

    Schiz Life
    15 Dec 2014 | 11:43 am
    Being a rare affliction itself, seasonal affective disorder is often overlooked when it comes to people dealing with schizophrenia due to depression often already being experienced.  But research has shown that not only are schizophrenia sufferers more susceptible to the extremes of SAD symptoms, but the rate of being diagnosed with the disorder itself is a full three times higher.  Understanding the subtle differences between standard major depression and seasonal depression can help individuals be more aware of their own internal state and safeguard against some of the dangers associated…
  • Mental Health Laws: Schizophrenia Advocacy

    Schiz Life
    5 Oct 2014 | 12:55 pm
    Twenty to 25% of the homeless populace in the United States have a serious mental illness, including schizophrenia, those with manic outbreaks, and those with severe depressive episodes. The mental health and legal systems are significantly failing these 9.6 million people creating a critical deficiency of services, such as community-based treatment, psychiatric prescriptions, and living accommodations. As a result, police are typically called to deal with incidents or disruptions triggered by the behavior of someone suffering with a serious mental disorder. Jails are the contemporary mental…
  • Is Schizophrenia 8 Distinct Disorders?

    Schiz Life
    18 Sep 2014 | 9:01 am
    We have all likely pondered over the many various types of schizophrenia and the wide range of symptoms that can manifest and realized how different some of them are.  It seems like we might be dealing with several distinct disorders from a surface viewpoint.  There has been little support for this concept “under the hood” when considering neurological and genetic factors, until now. “Multiple Genetically Distinct Disorders” Researchers at the Washington University School of Medicine reported some intriguing results in the American Journal of Psychiatry on the 15th…
  • Amy’s Story: Living with Schizophrenia

    Schiz Life
    6 Sep 2014 | 4:45 pm
    The following is a post by our friend Amy Kay, who has begun, recently and courageously, to voice and share her experiences with schizophrenia on her blog Voice of a Schizophrenic.  We are happy to share her story.. I used to tell people “I have a bad brain.” I am not going to say I suffer from schizophrenia but rather I endure and cope with it. My name is Amy Kay and I have schizophrenia. I do not want to hurt others or myself. Neither do I hear voices and I no longer live in a delusional world. In 2008 during my initial psychiatric breakdown it started with a state of euphoria.
  • New Schizophrenia Dimmer Switch Medication Concept

    Schiz Life
    12 Aug 2014 | 12:51 pm
    As we all know, schizophrenia medication can cause a rash of ill effects in it’s users, often times to the point that the disruption from the medication is subjectively worse than the symptoms of the illness they are meant to treat.  Finding the right balance of medications to properly treat the problem without creating addition side effects can be a long and drawn out process that is frustrating to the patient and the doctor.  However, a breakthrough in this process may have just occurred… Yesterday, the Monash University in Melbourne, Australia published its findings (read the…
 
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