Schizophrenia

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  • Abnormal Causal Connectivity by Structural Deficits in First-Episode, Drug-Naive Schizophrenia at Rest

    Schizophrenia Bulletin - Advance Access
    Guo, W., Liu, F., Liu, J., Yu, L., Zhang, J., Zhang, Z., Xiao, C., Zhai, J., Zhao, J.
    28 Aug 2014 | 12:25 am
    Anatomical deficits and resting-state functional connectivity (FC) alterations in prefrontal-thalamic-cerebellar circuit have been implicated in the neurobiology of schizophrenia. However, the effect of structural deficits in schizophrenia on causal connectivity of this circuit remains unclear. This study was conducted to examine the causal connectivity biased by structural deficits in first-episode, drug-naive schizophrenia patients. Structural and resting-state functional magnetic resonance imaging (fMRI) data were obtained from 49 first-episode, drug-naive schizophrenia patients and 50…
  • Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia

    Schizophrenia Bulletin - Advance Access
    Andreou, C., Nolte, G., Leicht, G., Polomac, N., Hanganu-Opatz, I. L., Lambert, M., Engel, A. K., Mulert, C.
    28 Aug 2014 | 12:25 am
    Background: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band…
  • Atypical Antipsychotic Drugs Used to Treat...

    About.com Schizophrenia: Most Popular Articles
    29 Aug 2014 | 6:39 am
    In the early 1990s a new class of drugs were developed to treat the psychotic symptoms of schizophrenia. These drugs, the atypical antipsychotics, have proven generally as effective as the antispychotics developed decades earlier, with fewer extrapyrimidal side effects. This list of the atypical antipsychotics provides links to drug safety information from the drug manufacturers' websites.
  • Discontinuation of antipsychotic medication in pregnancy: A cohort study

    Schizophrenia Research
    Irene Petersen, Rachel L. McCrea, David J.P. Osborn, Stephen Evans, Vanessa Pinfold, Phil J. Cowen, Ruth Gilbert, Irwin Nazareth
    25 Aug 2014 | 5:00 pm
  • Schizophrenia treatment improved with ACCESS

    Schizophrenia News
    28 Aug 2014 | 2:41 pm
    Patients treated for schizophrenia or bipolar I disorder under the ACCESS model have low levels of service disengagement, high levels of medication adherence and improvements in clinical outcomes, researchers report.
 
 
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    About.com Schizophrenia: What's Hot Now

  • Living With Schizophrenia

    schizophrenia.guide@about.com
    29 Aug 2014 | 4:24 am
    Schizophrenia is a chronic disease, and you should plan for times of remission and times of relapse. Even in remission, your residual symptoms (the symptoms you continue to have even when you’re relatively well) will effect all aspects of your life. This article from your About Guide to Schizophrenia gives you concrete suggestions to help you improve you independent living skills and social relationships.
  • The Positive and Negative Symptoms of...

    schizophrenia.guide@about.com
    29 Aug 2014 | 4:24 am
    Are you having experiences that seem unreal? Are you concerned about strange behavior in a loved one? Learn to understand and describe the symptoms of schizophrenia, so that you can communicate them to a doctor.
  • What It's Like to Have Schizophrenia

    schizophrenia.guide@about.com
    29 Aug 2014 | 4:24 am
    In schizophrenia, the most basic processes of perceiving and thinking are affected by the illness. Whether you want your loved ones to understand you better, are concerned for someone who's ill, or are simply curious, this article describes the internal experience of delusions, hallucinations, and more.
  • Schizophrenia Symptoms and Diagnosis

    schizophrenia.guide@about.com
    29 Aug 2014 | 4:24 am
    What are the main symptoms of schizophrenia? How is a diagnosis of schizophrenia made?
  • Who Gets Schizophrenia?

    schizophrenia.guide@about.com
    29 Aug 2014 | 4:24 am
    Although the overall incidence of schizophrenia in the United States is close to 1%, different groups have a greater or lesser likelihood of developing the illness. This article from your About Guide to Schizophrenia reviews the incidence of schizophrenia among different groups of people, which scientists are using as clues to help find the cause.
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    About.com Schizophrenia: Most Popular Articles

  • Are There Warning Signs That Raise a Red Flag...

    29 Aug 2014 | 6:39 am
    Are there any warning signs that raise a red flag for schizophrenia?
  • The Positive and Negative Symptoms of...

    29 Aug 2014 | 6:39 am
    Are you having experiences that seem unreal? Are you concerned about strange behavior in a loved one? Learn to understand and describe the symptoms of schizophrenia, so that you can communicate them to a doctor.
  • Positive Symptoms in Schizophrenia

    29 Aug 2014 | 6:39 am
    The positive symptoms are one of the symptoms clusters counting toward a diagnosis of schizophrenia. Start here for an overview that will help you understand what they are.
  • Atypical Antipsychotic Drugs Used to Treat...

    29 Aug 2014 | 6:39 am
    In the early 1990s a new class of drugs were developed to treat the psychotic symptoms of schizophrenia. These drugs, the atypical antipsychotics, have proven generally as effective as the antispychotics developed decades earlier, with fewer extrapyrimidal side effects. This list of the atypical antipsychotics provides links to drug safety information from the drug manufacturers' websites.
  • Questions Doctors Ask to Diagnose Schizophrenia

    29 Aug 2014 | 6:39 am
    Worried about having schizophrenia? You wonder what a psychiatrist will ask during the first visit? Here is what to expect.
 
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    Schizophrenia Bulletin - Advance Access

  • Abnormal Causal Connectivity by Structural Deficits in First-Episode, Drug-Naive Schizophrenia at Rest

    Guo, W., Liu, F., Liu, J., Yu, L., Zhang, J., Zhang, Z., Xiao, C., Zhai, J., Zhao, J.
    28 Aug 2014 | 12:25 am
    Anatomical deficits and resting-state functional connectivity (FC) alterations in prefrontal-thalamic-cerebellar circuit have been implicated in the neurobiology of schizophrenia. However, the effect of structural deficits in schizophrenia on causal connectivity of this circuit remains unclear. This study was conducted to examine the causal connectivity biased by structural deficits in first-episode, drug-naive schizophrenia patients. Structural and resting-state functional magnetic resonance imaging (fMRI) data were obtained from 49 first-episode, drug-naive schizophrenia patients and 50…
  • Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia

    Andreou, C., Nolte, G., Leicht, G., Polomac, N., Hanganu-Opatz, I. L., Lambert, M., Engel, A. K., Mulert, C.
    28 Aug 2014 | 12:25 am
    Background: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band…
  • The Effect of Clozapine on Premature Mortality: An Assessment of Clinical Monitoring and Other Potential Confounders

    Hayes, R. D., Downs, J., Chang, C.-K., Jackson, R. G., Shetty, H., Broadbent, M., Hotopf, M., Stewart, R.
    25 Aug 2014 | 8:37 am
    Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes. We identified 14 754 individuals (879 deaths) with serious mental illness (SMI) including schizophrenia, schizoaffective and bipolar disorders aged ≥ 15 years in a large specialist mental healthcare case register linked to national mortality tracing. In this cohort study we modeled the effect of clozapine on mortality over a 5-year period (2007–2011)…
  • Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137

    Warburton, A., Breen, G., Rujescu, D., Bubb, V. J., Quinn, J. P.
    25 Aug 2014 | 1:31 am
    MIR137 has been identified as a candidate gene for schizophrenia from genome-wide association studies via association with an intronic single nucleotide polymorphism (SNP), rs1625579. The location of the SNP suggests one mechanism in which transcriptional or posttranscriptional regulation of miR-137 expression could underlie schizophrenia. We identified and validated a novel promoter of the MIR137 gene adjacent to miR-137 itself which can direct the expression of distinct mRNA isoforms encoding miR-137. Analysis of both endogenous gene expression and reporter gene assays determined that this…
  • Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Patients With Schizophrenia

    Nielsen, J., Roge, R., Pristed, S. G., Viuff, A. G., Ullum, H., Thorner, L. W., Werge, T., Vang, T.
    25 Aug 2014 | 1:31 am
    Background: The etiology of schizophrenia remains largely unknown but alterations in the immune system may be involved. In addition to the psychiatric symptoms, schizophrenia is also associated with up to 20 years reduction in life span. Soluble urokinase-type plasminogen activator receptor (suPAR) is a protein that can be measured in blood samples and reflects the levels of inflammatory activity. It has been associated with mortality and the development of type 2 diabetes and cardiovascular disease. Methods: suPAR levels in patients with schizophrenia were compared to healthy controls from…
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    Schizophrenia News -- ScienceDaily

  • Difficulty assessing effort drives motivation deficits in schizophrenia, study finds

    21 Aug 2014 | 9:48 am
    Individuals with schizophrenia often have trouble engaging in daily tasks or setting goals for themselves, and a new study suggests the reason might be their difficulty in assessing the amount of effort required to complete tasks. The research can assist health professionals in countering motivation deficits among patients with schizophrenia and help those patients function normally by breaking up larger, complex tasks into smaller, easier-to-grasp ones.
  • Happiness in schizophrenia: Research suggests mental illness doesn’t preclude enjoying life

    18 Aug 2014 | 12:21 pm
    Schizophrenia is among the most severe forms of mental illness, yet some people with the disease are as happy as those in good physical and mental health, according to a new study. “People with schizophrenia are clearly less happy than those in the general population at large, but this is not surprising,” said the lead author. “What is impressive is that almost 40 percent of these patients are reporting happiness and that their happiness is associated with positive psychosocial attributes that can be potentially enhanced.”
  • Suspect gene corrupts neural connections: Diseases of synapses' demo'd in a dish

    17 Aug 2014 | 7:01 pm
    Researchers have demonstrated in patients' cells how a rare mutation in a suspect gene corrupts the turning on and off of dozens of other genes underlying synapses -- the connections between neurons. In a 'disease-in-a-dish' study, induced neurons of patients from families affected by a mutation associated with schizophrenia and other major mental illness expressed 80 percent lower-than-normal levels of a protein made by a suspect gene.
  • Stuck in neutral: Brain defect traps schizophrenics in twilight zone

    17 Aug 2014 | 7:00 pm
    People with schizophrenia struggle to turn goals into actions because brain structures governing desire and emotion are less active and fail to pass goal-directed messages to cortical regions affecting human decision-making, new research reveals.
  • Mind and body: Scientists identify immune system link to mental illness

    13 Aug 2014 | 2:42 pm
    Children with high everyday levels of a protein released into the blood in response to infection are at greater risk of developing depression and psychosis in adulthood, according to new research that suggests a role for the immune system in mental illness. The study indicates that mental illness and chronic physical illness such as coronary heart disease and type 2 diabetes may share common biological mechanisms.
 
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    Schizophrenia Society of Nova Scotia

  • The "From Recovery to Discovery" Mental Health Peer Support Group - Halifax

    29 Aug 2014 | 4:30 am
    This Thursday, September 4th, 6:30 pmMeetingsEvery Thursday Evening6:30 pm to 8:30 pmCommunity RoomAtlantic Superstore – Barrington Street 1075 Barrington StreetHalifax, Nova Scotia Plenty of free parking!The Atlantic Superstore – Barrington Street is on the 3, 7, 9, and 41 Metro Transit bus routes.The From Recovery to Discovery Mental Health Peer Support Group is open to anyone affected by any type of mental illness, and this includes family members and friends.Free! Thursday, September 4th, 2014, 6:30 pmAn Informal Interactive Conversation on the Windhorse ProjectwithJames…
  • HRM Family Education & Support Group

    29 Aug 2014 | 4:00 am
    Monday, September 8th, 7:00 pmHRM Chapter of the SSNSFamily Education & Support Group MeetingDateMonday, September 8th, 2014Time7:00 pm to 9:00 pmPlaceRoom 1243A, Halifax InfirmaryQueen Elizabeth II Health Sciences Centre1796 Summer StreetHalifax, Nova ScotiaAgenda7:00 pm to 9:00 pmAntipsychotics and their Side EffectswithDr. David M. GardnerProfessorDepartment of PsychiatryDalhousie UniversityDavid Gardner also holds joint appointments with the College of Pharmacy and Department of Pharmacology at Dalhousie University. He received his undergraduate degree in pharmacy from the University…
  • Support for Family and Friends of Persons Living with Mental Illness

    29 Aug 2014 | 3:30 am
    Monday, September 8th, 7:00 pmBerwickA Self-Help Group in Kings County, Nova ScotiaCaring for a loved one who is dealing with a mental illness can require emotional and practical support. You are not alone. This self-help group was started in the fall of 2008 to share personal experiences in response to the need of support for the families and friends of persons living with serious mental illness.While it originated through families involved in the Schizophrenia Society of Nova Scotia (SSNS), the group feels it can offer support to families dealing with a wide range of brain illnesses,…
  • Pictou County MI (Mental Illness) Family Support Group

    29 Aug 2014 | 3:00 am
    Tuesday, September 9th, 7:00 pmPictou County MI (Mental Illness) Family Support GroupFamily Education and Support Group MeetingThe Pictou County MI (Mental Illness) Family Support Group meets on the second Tuesday of every month (except July & August) at the Nova Scotia Community College in Stellarton.DateTuesday, September 9th, 2014Time7:00 pm to 9:00 pmPlaceNSCC Pictou CampusRoom B-120 (back entrance)39 Acadia AvenueStellarton, Nova ScotiaEveryone Welcome!For further information about The Pictou County MI (Mental Illness) Family Support Group, please contact Cecilia McRae or Elaine…
  • How to refer someone to the Nova Scotia Early Psychosis Program

    25 Aug 2014 | 4:00 am
    From the Nova Scotia Early Psychosis Program (NSEPP) website:Because NSEPP is located in Halifax, within the largest of the Nova Scotia health regions; Capital Health, the program provides direct clinical services to residents of the Capital Health district.Referrals to NSEPP can be made by anyone, including mental health care professionals, family physicians, community agencies, educators and school counselors, family members, friends and any young person who suspects they may be suffering from a first episode of psychosis.Criteria for referral of individuals who reside in the Capital Health…
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    schizophrenic.com

  • Schizophrenia risk doubles with vitamin D deficiency

    M Tyler
    26 Aug 2014 | 11:24 am
    Seventy-five percent of Americans have double the risk of schizophrenia due to vitamin D deficiency, according to a study published in the Journal of Clinical Endocrinology & Metabolism. Researcher Ahmad Esmaillzadeh, from Isfahan University of Medical Sciences, found that people with schizophrenia have lower vitamin D levels than healthy individuals. Other studies have shown that the disease is more common in colder climates, where sunlight is more scarce. “This is the first comprehensive meta-analysis to study the relationship between [vitamin D deficiency and schizophrenia],”…
  • Alkermes submits applications for schizophrenia drug aripiprazole

    M Tyler
    25 Aug 2014 | 8:46 am
    Biopharmaceutical company Alkermes plc announced today that it has submitted a New Drug Application to the FDA for approval of aripiprazole, a long-acting injectable schizophrenia medication. The drug is a once-monthly antipsychotic that, according to the company, was able to cause significant improvements in schizophrenia symptoms during a phase 3 study that assessed the efficacy and safety of aripiprazole. "Aripiprazole lauroxil was generally well tolerated in the study, and the observed safety profile of aripiprazole lauroxil was similar to that reported with oral aripiprazole," RTT News…
  • Schizophrenia doesn't mean you can't be happy, study says

    M Tyler
    20 Aug 2014 | 3:20 pm
    In a new study from the University of California, San Diego School of Medicine, researchers report that having schizophrenia doesn't necessarily mean a life sentence of gloom and doom. Some people with the disease are even as happy as individuals who are in good physical and mental health, the study found. Researchers surveyed 72 outpatients with schizophrenia in the San Diego area. All but nine patients were taking at least one anti-psychotic medication at the time of the survey and 59 percent were residing in assisted living facilities. According to senior author Dilip V. Jeste, MD,…
  • Brain structure prevents schizophrenics from turning goals into action

    M Tyler
    18 Aug 2014 | 2:32 pm
    For individuals with schizophrenia, turning goals into actions can be difficult due to the brain structures that govern desire and emotion, according to new research from the University of Sydney. The problem may stem from the fact that these brain areas fail to pass goal-related messages to other areas of the brain that rule decision-making. These findings could explain why schizophrenic patients often have challenges achieving goals like going to school, having normal social relationships or holding down jobs. "What appears to block them are specific brain deficits that prevent them from…
  • How the immune system may be linked to mental illness

    M Tyler
    15 Aug 2014 | 8:05 am
    The way the body responds to infection could shed light on how mental illness develops, according to a new study. Researchers from the University of Cambridge found that children with high levels of protein in the blood in response to infection are more likely to develop depression and psychosis as adults. The findings suggest physical illness and mental illness might share some of the same biological mechanisms, a press release on the study stated. How the body fights infection Exposure to any type of infection, like influenza, causes the immune system to release proteins into the blood…
 
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    Schiz Life

  • New Schizophrenia Dimmer Switch Medication Concept

    Schiz Life
    12 Aug 2014 | 12:51 pm
    As we all know, schizophrenia medication can cause a rash of ill effects in it’s users, often times to the point that the disruption from the medication is subjectively worse than the symptoms of the illness they are meant to treat.  Finding the right balance of medications to properly treat the problem without creating addition side effects can be a long and drawn out process that is frustrating to the patient and the doctor.  However, a breakthrough in this process may have just occurred… Yesterday, the Monash University in Melbourne, Australia published its findings (read the…
  • The 12 Core Functions: Your Therapist and Treatment Path

    Schiz Life
    20 Jul 2014 | 5:43 am
    The 12 Core Functions: Your Therapist and Treatment Path A sad reality is that many people dealing with the symptoms of schizophrenia simply fail to receive treatment.  There are lots of various reasons why this can happen, but one of the reasons is a resistance and fear in not understanding how treatment will transpire.  This article is meant to give the reader a general overview of what the therapist is thinking and the guidelines they follow to perform their task.  Your treatment will be personalized and tailored specifically to your experiences, symptoms, and receptiveness, but it will…
  • Schizophrenia Spectrum Disorders

    Schiz Life
    25 May 2014 | 1:52 pm
    What is schizophrenia spectrum disorder? How is it diagnosed and treated? A better understanding of this disorder might be derived from an understanding of the terms used to identify it. Schizophrenia is a mental disorder characterized by reduced emotional expression, abnormal social behavior and the inability to distinguish what is real and what isn’t. Persons with schizophrenia might talk about hearing voices, experience hallucinations, and suffer delusions. Spectrum refers to a range of linked conditions sometimes extending to include singular symptoms and disorders, as they relate…
  • Schizophrenia Risk Factors

    Schiz Life
    25 May 2014 | 1:39 pm
    Schizophrenia is a chronic mental disorder that adversely affects about 1 per cent of the global population. It is commonly described as someone being delusional, paranoid, and hallucinating, but that’s only one type of schizophrenia. Schizophrenia can occur at any age, but it tends to first progress between adolescence and early adulthood, normally between the ages of 16 – 30 years. It rarely occurs before adolescence or after age 45. It is more likely to worsen if left untreated. The illness itself cannot be cured but with sufficient medication, the symptoms can be controlled.
  • Movies About Schizophrenia

    Schiz Life
    24 May 2014 | 2:05 pm
    Schizophrenia is a devastating mental illness which affects approximately one in a hundred people. It usually strikes first in the early teenage years and involves hallucinations and delusions. It is one of those disorders that people find bizarre yet fascinating to learn about. Over the years, Hollywood has used the opportunity to bring top quality movies that depict this illness and at the same time shed some light on the severity to which it can affect persons. Why Movies About Schizophrenia Are Intriguing To Many Usually, movies about schizophrenia reconstruct the mental experiences of…
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